Erika Kirk publicly endorsed Vice President JD Vance for the presidency in 2028 at a Turning Point USA conference held in Arizona. During her speech at AmericaFest, the first major event since her husband's assassination, she expressed her commitment to mobilizing the influential conservative organization to support Vance's candidacy. Kirk stated, "We are going to get my husband’s friend JD Vance elected for 48 in the most resounding way possible."

Vance, who is viewed by some supporters as a key ally of former President Donald Trump, has not yet confirmed his intention to run in 2028. In a recent interview, he indicated that his current focus is on the vice presidency and the upcoming 2026 midterm elections, suggesting he would discuss his future plans with Trump after the elections.

The endorsement carries weight due to Turning Point USA's significant role in shaping the modern conservative movement, particularly among younger voters, since its founding by Charlie Kirk in 2012. Vance has acknowledged the impact of Charlie Kirk on his political career and the broader success of the Trump administration, attributing much of their achievements to Kirk's organizational skills.

Additionally, Secretary of State Marco Rubio has expressed his support for Vance should he decide to run, stating that he would back him as the nominee. Former President Trump has also commented positively on both Vance and Rubio as potential candidates, suggesting that their combined influence could be formidable in a presidential race.